Journal
JOURNAL OF AFFECTIVE DISORDERS
Volume 64, Issue 2-3, Pages 271-275Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-0327(00)00223-8
Keywords
depression; drug-resistant; transcranial magnetic stimulation
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Background: Controverted results have been obtained using high frequency transcranial magnetic stimulation (HF-rTMS) as an antidepressant treatment. Method: Forty patients suffering from drug-resistant major depression received ten sessions of HF-rTMS at 90%: of the motor threshold on the left prefrontal cortex or sham stimulation, added to their pharmacological treatment, in a randomized double-blind design. In a second open phase, patients still fulfilling criteria of inclusion received ten additional sessions of HF-rTMS at 90 or 110%. Results: Real, but not sham HF-rTMS, was associated with a significant decrease in the Hamilton Depression Rating Scale, but only twelve patients decreased more than 50%. Conclusions: Left prefrontal HF-rTMS was effectively associated with antidepressant treatment, although the size effect was small. Limitations: Shortage of the sample and control difficulties of the placebo effect. Clinical relevance: Questionable in more than half of the patients studied. (C) 2001 Elsevier Science B.V. All rights reserved.
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