Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 37, Issue -, Pages 167-172Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0370167
Keywords
cancer; endosomal sorting complex required for transport (ESCRT); endosome; multivesicular body (MVB); neurodegeneration; pathogenesis
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The ESCRT (endosomal sorting complex required for transport) machinery plays a critical role in receptor down-regulation, retroviral budding, and other normal and pathological processes. The ESCRT components are conserved in all five major subgroups of eukaryotes. This review summarizes the growing number of links identified between ESCRT-mediated protein sorting in the MVB (multivesicular body) pathway and various human diseases.
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