Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 37, Issue -, Pages 897-904Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0370897
Keywords
Dot1; histone 2AX (H2AX); histone methylation; mediator of DNA-damage checkpoint 1 (MDC1); p53-binding protein 1 (53BP1); Rad9
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53BP1 (p53-binding protein 1) is classified as a mediator/adaptor of the DNA-damage response, and is recruited to nuclear structures termed foci following genotoxic insult. In the present paper, we review the functions of S3BP1 in DNA-damage checkpoint activation and DNA repair, and the mechanisms of its recruitment and activation following DNA damage. We focus in particular on the role of covalent histone modifications in this process.
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