Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 37, Issue -, Pages 1198-1200Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0371198
Keywords
angiogenesis; arteriogenesis; gene therapy; ischaemia; lymphangiogenesis; vascular endothelial growth factor (VEGF)
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Funding
- Academy of Finland
- Leducq Foundation
- European Union [LSHG-CT-2004-503573, LSHB-CT-2006-018933]
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Therapeutic angiogenesis is a promising new concept for the treatment of myocardial and peripheral ischaemia. Members of the VEGF (vascular endothelial growth factor) family are among the most powerful modulators of angiogenesis. They regulate vascular growth and maintenance during embryogenesis and in adults. The present review summarizes the current status of therapeutic angiogenesis using VEGF, with special reference to preclinical studies.
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