Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 36, Issue -, Pages 411-415Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0360411
Keywords
cell cycle; cytokinesis; fission yeast; kinase; septation initiation network (SIN)
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The fission yeast septation initiation network, or SIN, is a signal transduction network that is required for septum formation in Schizosoccharomyces pombe. Its activity is tightly regulated through the cell cycle, to ensure proper co-ordination of mitosis and cytokinesis. SIN signalling requires three protein kinases for its function and is mediated by a ras-superfamily GTPase. We discuss the elements of the SIN and how they are regulated.
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