Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 36, Issue -, Pages 263-266Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0360263
Keywords
Dok1; fibronectin; filamin; focal adhesion; integrin; talin
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Funding
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- Wellcome Trust Funding Source: Medline
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Recent studies of some proteins involved in the formation of focal adhesions are described. These include fibronectin, integrins, talin, Dok1 and filamin. Emphasis is placed on features that facilitate regulated assembly of complexes; these include a modular construction and flexible regions that provide interaction sites whose affinity can be adjusted by conformational masking and phosphorylation.
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