Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 36, Issue -, Pages 280-285Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0360280
Keywords
betacellulin; epidermal growth factor (EGF); ErbB; pancreatic beta-cell; transdifferentiation
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Pancreatic islet development is impaired in mice lacking EGFRs (epidermal growth factor receptors). Even partial tissue-specific attenuation of EGFR signalling in the islets leads to markedly reduced p-cell proliferation and development of diabetes during the first weeks after birth. out of the many EGFR ligands, betacellulin has been specifically associated with positive effects on beta-cell growth, through both increased proliferation and neogenesis. EGFR action is also necessary for the beta-cell mitogenic activity of the gut hormone GLP-1 (glucagon-like peptide 1). Finally, in vitro models demonstrate a central role for EGFR in transdifferentiation of pancreatic acinar and ductal cells into endocrine islet cells. EGFR thus plays an essential role in p-cell mass regulation, but its mechanisms of action remain poorly understood.
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