Journal
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
Volume 9, Issue 2, Pages 209-214Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/1064-1297.9.2.209
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Funding
- NIDA NIH HHS [P01 DA000254, DA00254] Funding Source: Medline
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This study validated a human behavioral model of thermal nociception analogous to the rodent tail-flick assay. Effects of instructions and stimulus intensity on behavior (i.e., finger withdrawal latency) were evaluated. Using a repeated measures randomized crossover design, the authors exposed 10 volunteers to varying radiant heat intensities (from 42.2 to 52.2 degreesC) during each of four sessions. In the different sessions, participants were told to remove their finger when they felt heat, felt unpleasant, felt pain, or could no longer tolerate pain. Withdrawal latencies significantly decreased as stimulus intensity increased and significantly increased for sensory, affective, pain, and intolerance instructions. Instruction set differences were significantly larger at higher stimulus intensities. This technique may be useful in human psychopharmacological research.
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