4.2 Article

Hypopituitarism due to pituitary metastasis of lung cancer: Case of a 21-year-old man

Journal

INTERNAL MEDICINE
Volume 40, Issue 5, Pages 414-417

Publisher

JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.40.414

Keywords

squamous cell carcinoma; pituitary metastasis; pituitary function test; young age; quality of life

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A 21-year-old man presented persistent dry cough, general malaise, loss of appetite, decreased sexual desire and double vision. Chest radiograph revealed a mass shadow in the left upper lobe, Histopathological diagnosis of the tumor was squamous cell carcinoma, Brain computed tomography and magnetic resonance imaging revealed a metastasis to the pituitary gland. Hypopituitarism was diagnosed by pituitary function tests. Diabetes insipidus was absent and the function of the posterior lobe of the pituitary gland was preserved. Hypopituitarism due to pituitary metastasis is a rare complication of lung cancer, and has never been reported in a patient as young as 21 years old.

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