Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 290, Issue 48, Pages 28596-28603Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R115.652750
Keywords
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor AMPAR); glutamate receptor; post-translational modification (PTM); protein palmitoylation; ubiquitin; N-methyl-D-aspartate receptor (NMDA receptor NMDAR)
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Funding
- Universite du Quebec a Montreal Start-up Funds
- National Institutes of Health NIA Grant [1K99AG041225]
- NINDS Intramural Program
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Many molecular mechanisms underlie the changes in synaptic glutamate receptor content that are required by neuronal networks to generate cellular correlates of learning and memory. During the last decade, posttranslational modifications have emerged as critical regulators of synaptic transmission and plasticity. Notably, phosphorylation, ubiquitination, and palmitoylation control the stability, trafficking, and synaptic expression of glutamate receptors in the central nervous system. In the current review, we will summarize some of the progress made by the neuroscience community regarding our understanding of phosphorylation, ubiquitination, and palmitoylation of the NMDA and AMPA subtypes of glutamate receptors.
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