Journal
JOURNAL OF NATURAL PRODUCTS
Volume 64, Issue 5, Pages 683-685Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np000441w
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Acetylcholinesterase (AChE) inhibitory activity-guided fractionation of Angelica gigas led to isolation and identification of a new coumarin, peucedanone (12), and isolation of 11 known coumarins. Among them, decursinol (1) represented the highest inhibitory activity toward AChE in vitro. The correlation of the inhibitory activities of the coumarins toward AChE with their chemical structures was studied.
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