Journal
BIOCHEMICAL PHARMACOLOGY
Volume 85, Issue 5, Pages 689-703Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2012.10.019
Keywords
Hydrogen sulfide; NSAIDs; Cancer prevention; Inflammation; Cardiovascular
Categories
Funding
- NIH [R24 DA018055]
- NSF IOS [1051627]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1051627] Funding Source: National Science Foundation
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Hydrogen sulfide, H2S, is a colorless gas with a strong odor that until recently was only considered to be a toxic environmental pollutant with little or no physiological significance. However, the past few years have demonstrated its role in many biological systems and it is becoming increasingly clear that H2S is likely to join nitric oxide (NO) and carbon monoxide (CO) as a major player in mammalian biology. In this review, we have provided an overview of the chemistry and biology of H2S and have summarized the chemistry and biological activity of some natural and synthetic H2S-donating compounds. The naturally occurring compounds discussed include, garlic, sulforaphane, erucin, and iberin. The synthetic H2S donors reviewed include, GYY4137; cysteine analogs; S-propyl cysteine, S-allyl cysteine, S-propargyl cysteine, and N-acetyl cysteine. Dithiolethione and its NSAID and other chimeras such as, L-DOPA, sildenafil, aspirin, diclofenac, naproxen, ibuprofen, indomethacin, and mesalamine have also been reviewed in detail. The newly reported NOSH-aspirin that releases both NO and H2S has also been discussed. (C) 2012 Elsevier Inc. All rights reserved.
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