Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 290, Issue 48, Pages 28623-28630Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R115.657130
Keywords
neuron; protein degradation; protein synthesis; protein turnover; synapse; synaptic plasticity
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Funding
- Marie Curie Intra-European Fellowship (IEF) for Career Development
- Max Planck Society
- European Research Council
- DFG [CRC 902, CRC1080]
- Molecular Principles of RNA-based Regulation
- Molecular and Cellular Mechanisms of Neural Homeostasis
- DFG Cluster of Excellence for Macromolecular Complexes, Goethe University, Frankfurt
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Emerging evidence indicates that protein synthesis and degradation are necessary for the remodeling of synapses. These two processes govern cellular protein turnover, are tightly regulated, and are modulated by neuronal activity in time and space. The anisotropic anatomy of the neurons presents a challenge for the study of protein turnover, but the understanding of protein turnover in neurons and its modulation in response to activity can help us to unravel the fine-tuned changes that occur at synapses in response to activity. Here we review the key experimental evidence demonstrating the role of protein synthesis and degradation in synaptic plasticity, as well as the turnover rates of specific neuronal proteins.
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