Journal
GENOMICS
Volume 73, Issue 3, Pages 272-283Publisher
ACADEMIC PRESS INC
DOI: 10.1006/geno.2000.6503
Keywords
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Funding
- NIDCD NIH HHS [DC01508, DC00189-01] Funding Source: Medline
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We report the isolation and initial characterization of a new member of the human nicotinic acetylcholine receptor (nAChR) subunit family, alpha 10 (CHRNA10), from both inner-ear neuroepithelium and lymphoid tissue. The cDNA is 1959 nucleotides in length, with a coding region predicting a protein of 451 amino acids that is 90% identical to rat alpha 10. The alpha 10 gene was localized to chromosome 11p15.5. Human alpha 10 was detected inhuman inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes using reverse transcriptase-polymerase chain reaction, Northern blot hybridization, and immunohistochemistry. We also detected the expression of the human nAChR alpha9 (CHRNA9) mRNA in these same tissues using RT-PCR and Northern blot hybridization. (C) 2001 Academic Press.
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