Journal
NEUROPSYCHOPHARMACOLOGY
Volume 24, Issue 5, Pages 467-477Publisher
NATURE PUBLISHING GROUP
DOI: 10.1016/S0893-133X(00)00228-1
Keywords
suicide; suicide attempt; candidate genes; serotonin; neuro-receptors
Categories
Funding
- NIAAA NIH HHS [AA09004] Funding Source: Medline
- NIMH NIH HHS [MH46745, MH40695, MH56390, MH55123, MH56612, MH40210] Funding Source: Medline
Ask authors/readers for more resources
Numerous abnormalities have been found in file serotonergic system in suicide attempters and completers. There is considerable evidence that the serotonergic system is partly under genetic control and that as yet unknown genetic factors mediate the risk for suicidal behavior independently of the genetic factors responsible for the heritability of major psychiatric conditions associated with suicide. An argument is made that there is a relationship of genetic variants to intermediate phenotypes, such as impulsivity, psychomotor change, pathological aggression and biological abnormalities including specific gene products. A variety of biological indices have been generated by new approaches using postmortem tissue and in vivo imaging that a,ill pr ovine a rich substrate for further genetic studies. [Neuropsychopharmacology 24:467-477,2001] (C) 2001 American College of Neuropsychopharamacology. Published by Elsevier Science Inc..
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available