Related references
Note: Only part of the references are listed.VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis
Galina I. Lepesheva et al.
JOURNAL OF INFECTIOUS DISEASES (2015)
How to bolster the antifungal pipeline
David W. Denning et al.
SCIENCE (2015)
A simple method for the determination of reduction potentials in heme proteins
Igor Efimov et al.
FEBS LETTERS (2014)
Sequence variation in CYP51A from the Y strain of Trypanosoma cruzi alters its sensitivity to inhibition
Tatiana S. Cherkesova et al.
FEBS LETTERS (2014)
Elucidating drug resistance in human fungal pathogens
Jinglin Lucy Xie et al.
FUTURE MICROBIOLOGY (2014)
Therapeutic drug monitoring (TDM) of antifungal agents: guidelines from the British Society for Medical Mycology
H. Ruth Ashbee et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2014)
Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition
Laura Friggeri et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Paralog Re-Emergence: A Novel, Historically Contingent Mechanism in the Evolution of Antimicrobial Resistance
Nichola J. Hawkins et al.
MOLECULAR BIOLOGY AND EVOLUTION (2014)
In Vitro and In Vivo Studies of the Antiparasitic Activity of Sterol 14α-Demethylase (CYP51) Inhibitor VNI against Drug-Resistant Strains of Trypanosoma cruzi
Maria de Nazare Correia Soeiro et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)
Aspergillosis due to Voriconazole Highly Resistant Aspergillus fumigatus and Recovery of Genetically Related Resistant Isolates From Domiciles
Jan W. M. van der Linden et al.
CLINICAL INFECTIOUS DISEASES (2013)
Complexes of Trypanosoma cruzi Sterol 14α-Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease STRUCTURAL BASIS FOR PATHOGEN SELECTIVITY
Tatiana Y. Hargrove et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
VNI Cures Acute and Chronic Experimental Chagas Disease
Fernando Villalta et al.
JOURNAL OF INFECTIOUS DISEASES (2013)
Antitrypanosomal Lead Discovery: Identification of a Ligand-Efficient Inhibitor of Trypanosoma cruzi CYP51 and Parasite Growth
Grasiella Andriani et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Characterization of the sterol 14α-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 function
Jieru Fan et al.
NEW PHYTOLOGIST (2013)
Global burden of allergic bronchopulmonary aspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults
David W. Denning et al.
MEDICAL MYCOLOGY (2013)
Structural Basis for Effector Control and Redox Partner Recognition in Cytochrome P450
Sarvind Tripathi et al.
SCIENCE (2013)
Antifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1
Natalia Mast et al.
MOLECULAR PHARMACOLOGY (2013)
Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Δ7-24, 25-dihydrolanosterol
Tatiana Y. Hargrove et al.
JOURNAL OF LIPID RESEARCH (2012)
Hidden Killers: Human Fungal Infections
Gordon D. Brown et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds
Tatiana Y. Hargrove et al.
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE (2012)
Structural basis for conservation in the CYP51 family
Galina I. Lepesheva et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2011)
Cytochrome P450 7A1 Cholesterol 7α-Hydroxylation INDIVIDUAL REACTION STEPS IN THE CATALYTIC CYCLE AND RATE-LIMITING FERRIC IRON REDUCTION
Raku Shinkyo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantum
Tatiana Y. Hargrove et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease
Rebecca S. Shapiro et al.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2011)
Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system
Natallia Strushkevich et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Features and development of Coot
P. Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
PHENIX: a comprehensive Python-based system for macromolecular structure solution
Paul D. Adams et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)
Expression, Purification, and Characterization of Aspergillus fumigatus Sterol 14-α Demethylase (CYP51) Isoenzymes A and B
Andrew G. S. Warrilow et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Antifungal therapy in invasive fungal infections
Sharon C-A Chen et al.
CURRENT OPINION IN PHARMACOLOGY (2010)
Crystal Structures of Trypanosoma brucei Sterol 14α-Demethylase and Implications for Selective Treatment of Human Infections
Galina I. Lepesheva et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Structural Insights into Inhibition of Sterol 14α-Demethylase in the Human Pathogen Trypanosoma cruzi
Galina I. Lepesheva et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Invasive Fungal Infections The Challenge Continues
Antonino Gullo
DRUGS (2009)
Sterol 14α-demethylase as a potential target for antitrypanosomal therapy:: Enzyme inhibition and parasite cell growth
Galina I. Lepesheva et al.
CHEMISTRY & BIOLOGY (2007)
Conformational dynamics in the F/G segment of CYP51 from Mycobacterium tuberculosis monitored by FRET
Galina I. Lepesheva et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2007)
Phaser crystallographic software
Airlie J. McCoy et al.
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)
Sterol 14 alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms
Galina I. Lepesheva et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2007)
Cyp51 from Trypanosoma cruzi -: A phyla-specific residue in the B′ helix defines substrate preferences of sterol 14α-demethylase
GI Lepesheva et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
The integration of macromolecular diffraction data
AGW Leslie
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2006)
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
WC Nierman et al.
NATURE (2005)
Redox and spectroscopic properties of human indoleamine 2,3-dioxygenase and a His303Ala variant: Implications for catalysis
ND Papadopoulou et al.
BIOCHEMISTRY (2005)
A simple and rapid method to measure cholesterol binding to P450s and other proteins
N Mast et al.
JOURNAL OF LIPID RESEARCH (2005)
The invasive and saprophytic syndromes due to Aspergillus spp.
WW Hope et al.
MEDICAL MYCOLOGY (2005)
CYP51 from Trypanosoma brucei is obtusifoliol-specific
GI Lepesheva et al.
BIOCHEMISTRY (2004)
Conservation in the CYP51 family.: Role of the B′ helix/BC loop and helices F and G in enzymatic function
GI Lepesheva et al.
BIOCHEMISTRY (2003)
Voriconazole: A new triazole antifungal agent
LB Johnson et al.
CLINICAL INFECTIOUS DISEASES (2003)
Molecular basis of resistance to azole antifungals
A Lupetti et al.
TRENDS IN MOLECULAR MEDICINE (2002)
Identification of two different 14-α sterol demethylase-related genes (cyp51A and cyp51B) in Aspergillus fumigatus and other aspergillus species
E Mellado et al.
JOURNAL OF CLINICAL MICROBIOLOGY (2001)
Share Paper
