Journal
AMERICAN JOURNAL OF PSYCHIATRY
Volume 158, Issue 5, Pages 805-807Publisher
AMER PSYCHIATRIC PRESS, INC
DOI: 10.1176/appi.ajp.158.5.805
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Objective: The authors compared low-dose sustained-release bupropion with placebo for sexual dysfunction induced by selective serotonin reuptake inhibitors (SSRIs). Method: Thirty adults who had received SSRIs for at least 6 weeks, who were euthymic, and who had sexual dysfunction as determined by a total score greater than 19 out of a possible 30 on the Arizona Sexual Experience Scale were randomly assigned to receive either 150 mg/day of sustained-release bupropion or placebo at 6:00 p.m. for 3 weeks. Results: There were no significant differences between the sustained-release bupropion and placebo groups as measured by change in Arizona Sexual Experiences Scale or Hamilton Depression Rating Scale scores or side effects. Conclusions: Future studies should compare higher doses of bupropion for treating sexual dysfunction and should include a greater number of subjects.
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