Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 29, Issue -, Pages 241-245Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0290241
Keywords
fatty acid oxidation; fuel homoeostasis; malonyl-CoA; sperm development
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Funding
- NIDDK NIH HHS [DK 18573] Funding Source: Medline
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Although malonyl-CoA was first recognized as a central component in the regulation of hepatic ketogenesis, its inhibitory effect on mitochondrial carnitine palmitoyltransferase I (CPT I) has come to be viewed as a key element in fuel sensing in a variety of body tissues. This broadening role of the malonyl-CoA/CPT I partnership in the control of glucose and fatty acid metabolism, as well as current understanding of structure-function relationships surrounding the CPT proteins, are outlined. The intriguing question of whether CPT I has an important function in sperm development is also addressed briefly.
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