Journal
MECHANISMS OF DEVELOPMENT
Volume 103, Issue 1-2, Pages 145-148Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(01)00337-9
Keywords
FRS2; FRS3; SNT1; SNT2; FRS2 alpha; FRS2 beta; neural tube; nerve growth factor; fibroblast growth factor; Trk receptors; neurotrophins; gene expression; signaling adaptor protein; mouse; embryogenesis; embryo; patterning; RNA; in situ; PCR
Categories
Ask authors/readers for more resources
Two fibroblast growth factor (FGF) receptor substrates (FRS2 and FRS3) are involved in downstream signaling from activated FGF receptors and neurotrophin-activated Trk receptors. Despite the importance of signaling from these factors in embryogenesis, FRS2 and FRS3 expression patterns during development are unknown. In this study we characterize the expression of FRS3 and FRS3 from E7 to parturition and in adult murine tissues. Both are first detected in whole E8.5 CD1 mouse embryos. FRS2 is detected as early as E7 in the developing syncytiotrophoblast, later in the neural tube (NT) and in many adult and fetal tissues. FRS3 is more restricted in location than FRS2 (fetal NT, heart, stomach, liver and some adult tissues), and is expressed predominantly in the ventricular layer of the developing NT and brains of murine embryos. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available