Journal
BIOCHEMICAL PHARMACOLOGY
Volume 80, Issue 12, Pages 1833-1843Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2010.07.021
Keywords
Inflammation; Diabetes; Cancer; NF-kappa B; Curcumin; Nutraceuticals; Nanotechnology
Categories
Funding
- National Institutes of Health [NIH CA-16672, NIH CA-124787-01A2]
- Center for Targeted Therapy at The University of Texas MD Anderson Cancer Center
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Extensive research within the last two decades has revealed that most chronic illnesses, including cancer, diabetes, and cardiovascular and pulmonary diseases, are mediated through chronic inflammation. Thus, suppressing chronic inflammation has the potential to delay, prevent, and even treat various chronic diseases, including cancer. Various nutraceuticals from fruits, vegetables, vitamins, spices, legumes, and traditional Chinese and Ayurvedic medicine have been shown to safely suppress proinflammatory pathways; however, their low bioavailability in vivo limits their use in preventing and treating cancer. We describe here the potential of nanotechnology to fill this gap. Several nutraceuticals, including curcumin, green tea polyphenols, coenzyme Q quercetin, thymoquinone and others, have been packaged as nanoparticles and proven to be useful in nanochemoprevention and nanochemotherapy. (C) 2010 Elsevier Inc. All rights reserved.
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