Journal
PHARMACOLOGICAL RESEARCH
Volume 43, Issue 5, Pages 497-502Publisher
ACADEMIC PRESS LTD
DOI: 10.1006/phrs.2001.0813
Keywords
duodenal administration; intravenous administration; tobramycin-loaded solid lipid nanoparticles; tobramycin tissue distribution; blood-brain barrier
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Tobramycin-loaded solid lipid nanoparticles (SLN) were prepared and administered by duodenal and intravenous (i.v.) routes to rats and the tissue distributions were determined successively at fixed times (30 min, 4 h and 24 h) and compared to those of the tobramycin solution after i.v. administration. The tissue distribution between tobramycin-loaded SLN administered duodenally and i.v. was different.. A marked difference between tobramycin-loaded SLN administered duodenally and tobramycin solution administered i.v. was also evidenced. In particular, the amounts of tobramycin in the kidneys after tobramycin-loaded SLN administration either duodenally or i.v. were lower than after administration of i.v. solution. Tobramycin-loaded SLN were able to pass across the blood-brain barrier in rats to a greater extent after i.v. injection than after duodenal administration. (C) 2001 Academic Press.
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