Journal
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
Volume 5, Issue 5, Pages 486-489Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/jpp.351
Keywords
photodynamic therapy; chlorin e6; immunoconjugate
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Chlorin e6 (Ce6) was conjugated with anti-tumor monoclonal antibody (IgG2b) to increase its binding affinity for tumors. The Ce6 was activated by N-hydroxysuccinimide and directly conjugated with IgG2b (IgG2b-Ce6) via peptide bonds. An average of 11 Ce6 molecules were coupled to each IgG2b molecule. IgG2b-Ce6 showed high cellular uptake in tumor cells and high photocytotoxicity. These results indicate IgG2b-Ce6 is a good photosensitizer with high binding affinity to tumor cells. Copyright (C) 2001 John Wiley & Sons, Ltd.
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