Journal
JOURNAL OF VIROLOGY
Volume 75, Issue 10, Pages 4843-4853Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.75.10.4843-4853.2001
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Human herpesvirus 8 (HHV-8), a gammaherpesvirus implicated in Kaposi's sarcoma, primary effusion lymphoma, and Castleman's disease, encodes several pathogenically important cellular homologs. To define the HHV-8 transcription program, RNA obtained from latently infected body cavity-based lymphoma 1 cells induced to undergo lytic replication was used to query a custom HHV-8 DNA microarray containing nearly every known viral open reading frame. The patterns of viral gene expression offer insights into the replication and pathogenic strategies of HHV-8.
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