Journal
HISTOCHEMISTRY AND CELL BIOLOGY
Volume 115, Issue 5, Pages 359-372Publisher
SPRINGER
DOI: 10.1007/s004180100268
Keywords
skeletal muscle; fiber type; myofibrillar protein isoforms; fiber type transitions; muscle plasticity
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Skeletal muscle is a complex, versatile tissue composed of a large variety of functionally diverse fiber types. The overall properties of a muscle largely result from a combination of the individual properties of its different fiber types and their proportions. Skeletal muscle fiber types, which can be delineated according to various parameters, for example, myofibrillar protein isoforms, metabolic enzyme profiles, and structural and contractile properties, are not fixed units but are capable of responding to altered functional demands and a variety of signals by changing their phenotypic profiles. This brief review summarizes our current understanding of the delineation of fiber types, modulations of their phenotypic profiles as induced under various conditions, and potential mechanisms involved in these transitions.
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