Journal
BIOCHEMICAL PHARMACOLOGY
Volume 77, Issue 8, Pages 1316-1327Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2008.11.026
Keywords
LXRs; Cholesterol homeostasis; Liver steatosis; LXR ligands; Atherosclerosis
Categories
Funding
- Institut National de la Sante et de la Recherche Scientifique
- Fondation Coeur et Arteres
- Region Nord Pas de Calais/FEDER
- [201608]
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Liver X receptors (LXRs) are nuclear receptors that play a crucial role in regulating the expression of genes involved in lipid metabolism. Ligand activation of LXRs improves cholesterol homeostasis via multiple coordinated effects, and this function is likely to explain in part the protective effects of LXR activation on atherosclerosis reported in animal models. However, LXR activation may also induce undesirable side effects, such as lipogenesis and hypertriglyceridemia. This review discusses the potential to develop LXR modulators as therapeutic agents for atherosclerosis. (C) 2008 Elsevier Inc. All rights reserved.
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