Journal
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
Volume 27, Issue 3, Pages 141-150Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1023/A:1011365401976
Keywords
peptide aldehydes; chemical synthesis; enzyme synthesis; protease inhibitors
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Various synthetic approaches to modified peptides with the C-terminal aldehyde group, capable of inhibiting a number of proteolytic enzymes belonging to the classes of thiol, serine, and aspartyl proteases, are considered. Both chemical methods, including solid phase peptide synthesis now widely used, and biocatalytic synthetic methods for obtaining these substances are discussed in detail.
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