Journal
INFECTION AND IMMUNITY
Volume 69, Issue 5, Pages 3410-3412Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.69.5.3410-3412.2001
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Funding
- NHLBI NIH HHS [R01 HL059842, HL59842] Funding Source: Medline
- NIAID NIH HHS [AI33774, R01 AI033774, AI01489, AI13342] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007491, 5T32GM07491] Funding Source: Medline
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Passive immunization with monoclonal antibodies (MAbs) to melanin prolonged the survival of and reduced the fungal burden in Cryptococcus neoformans-infected mice in comparison to controls, MAbs to melanin reduced the growth rate of in vitro-melanized C. neoformans cells, suggesting a new mechanism of antibody-mediated protection.
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