Journal
BIOCHEMICAL PHARMACOLOGY
Volume 75, Issue 1, Pages 112-133Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2007.07.031
Keywords
homer proteins; addiction; glutamate; nucleus accumbens; prefronal cortex; prenatal stress
Categories
Funding
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R21AA015351, R01AA016650, U01AA016650] Funding Source: NIH RePORTER
- NIAAA NIH HHS [AA-0135017, AA-016650, R01 AA016650, AA-015351, U01 AA016650, R21 AA015351-01A2, R21 AA015351, U01 AA016650-01] Funding Source: Medline
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Drug addiction is a chronic, relapsing disorder, characterized by an uncontrollable motivation to seek and use drugs. Converging clinical and preclinical observations implicate pathologies within the corticolimbic glutamate system in the genetic predisposition to, and the development of, an addicted phenotype. Such observations pose cellular factors regulating glutamate transmission as likely molecular candidates in the etiology of addiction. Members of the Homer family of proteins regulate signal transduction through, and the trafficking of, glutamate receptors, as well as maintain and regulate extracellular glutamate levels in corticolimbic brain regions. This review summarizes the existing data implicating the Homer family of protein in acute behavioral and neurochemical sensitivity to drugs of abuse, the development of drug-induced neuroplasticity, as well as other behavioral and cognitive pathologies associated with an addicted state. (C) 2007 Elsevier Inc. All rights reserved.
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