Journal
FEMS MICROBIOLOGY LETTERS
Volume 198, Issue 2, Pages 129-134Publisher
ELSEVIER SCIENCE BV
DOI: 10.1111/j.1574-6968.2001.tb10631.x
Keywords
veterinary isolate; multidrug efflux; Pseudomonas aeruginosa
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The contribution of efflux pumps to multidrug resistance in 12 Pseudomonas aeruginosa isolates from various animal sources was assessed. Western immunoblot analyses demonstrated that ail twelve isolates expressed significant levels of the MexAB-OprM efflux system whereas two isolates simultaneously expressed the MexEF-OprN or MexXY systems, respectively.. One strain contained a single mutation in mexR. a regulator of mexAB oprM expression, that did not adversely affect the MexR amino acid sequence, and three isolates contained the same, single base change in the mexA-mexR intergenic region. The MexXY-expressing strain contained two base substitutions in its mex Z regulatory gene which did not alter the MexR sequence. (C) 2001 Federation of European Microbiological Societies. published by Elsevier Science B.V. All rights reserved.
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