4.5 Review

RBR E3 ubiquitin ligases: new structures, new insights, new questions

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination

Meredith B. Metzger et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)

Article Biochemistry & Molecular Biology

Mammalian HECT ubiquitin-protein ligases: Biological and pathophysiological aspects

Martin Scheffner et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)

Article Biochemistry & Molecular Biology

Ataxin-3 Is a Multivalent Ligand for the Parkin Ubl Domain

Jane J. Bai et al.

BIOCHEMISTRY (2013)

Article Biochemistry & Molecular Biology

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin

Kirstin Keusekotten et al.

Article Biochemistry & Molecular Biology

TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes

Ian R. Kelsall et al.

EMBO JOURNAL (2013)

Article Biochemistry & Molecular Biology

Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells

Yoshiteru Sasaki et al.

EMBO JOURNAL (2013)

Article Biochemistry & Molecular Biology

Structure of the human Parkin ligase domain in an autoinhibited state

Tobias Wauer et al.

EMBO JOURNAL (2013)

Article Biochemistry & Molecular Biology

AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinsons disease

Joseph Haskin et al.

HUMAN MOLECULAR GENETICS (2013)

Article Biochemistry & Molecular Biology

Target Specificity of the E3 Ligase LUBAC for Ubiquitin and NEMO Relies on Different Minimal Requirements

Judith J. Smit et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation

Masahiro Iguchi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO

Anne Kathrin Mueller-Rischart et al.

MOLECULAR CELL (2013)

Article Biochemistry & Molecular Biology

OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

Berthe Katrine Fiil et al.

MOLECULAR CELL (2013)

Article Multidisciplinary Sciences

The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis

Elena Rivkin et al.

NATURE (2013)

Article Multidisciplinary Sciences

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

Shireen A. Sarraf et al.

NATURE (2013)

Article Multidisciplinary Sciences

Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP

Benjamin Stieglitz et al.

NATURE (2013)

Article Biochemistry & Molecular Biology

Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming

Elena Maspero et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Essentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3

Hao Dou et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)

Article Biochemistry & Molecular Biology

PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21WAF1 and p63

F. Conforti et al.

ONCOGENE (2013)

Article Multidisciplinary Sciences

Structure of the HHARI Catalytic Domain Shows Glimpses of a HECT E3 Ligase

Donald E. Spratt et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

Profiling of Parkin-Binding Partners Using Tandem Affinity Purification

Alessandra Zanon et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

Christoph H. Emmerich et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

Jean-Francois Trempe et al.

SCIENCE (2013)

Article Multidisciplinary Sciences

A molecular explanation for the recessive nature of parkin-linked Parkinson's disease

Donald E. Spratt et al.

NATURE COMMUNICATIONS (2013)

Article Multidisciplinary Sciences

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

B. E. Riley et al.

NATURE COMMUNICATIONS (2013)

Review Biochemistry & Molecular Biology

Regulation of Parkin E3 ubiquitin ligase activity

Helen Walden et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

Article Biochemistry & Molecular Biology

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

Kelly Verhelst et al.

EMBO JOURNAL (2012)

Article Biochemistry & Molecular Biology

A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex

Hirokazu Yagi et al.

EMBO REPORTS (2012)

Article Biochemistry & Molecular Biology

LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

Benjamin Stieglitz et al.

EMBO REPORTS (2012)

Article Biochemistry & Molecular Biology

TRIAD1 inhibits MDM2-mediated p53 ubiquitination and degradation

Seunghee Bae et al.

FEBS LETTERS (2012)

Article Biochemistry & Molecular Biology

Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential

Yukiko Kuroda et al.

HUMAN MOLECULAR GENETICS (2012)

Article Biochemistry & Molecular Biology

Differential regulation of PML-RARet stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1

Kristin Pietschmann et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Ataxin-3 Deubiquitination Is Coupled to Parkin Ubiquitination via E2 Ubiquitin-conjugating Enzyme

Thomas M. Durcan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Cell Biology

HECT and RING finger families of E3 ubiquitin ligases at a glance

Meredith B. Metzger et al.

JOURNAL OF CELL SCIENCE (2012)

Article Neurosciences

Neddylation positively regulates the ubiquitin E3 ligase activity of parkin

Ji Won Um et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2012)

Article Biochemistry & Molecular Biology

Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases

Jonathan N. Pruneda et al.

MOLECULAR CELL (2012)

Article Biochemistry & Molecular Biology

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

Rune Busk Damgaard et al.

MOLECULAR CELL (2012)

Article Multidisciplinary Sciences

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

Anna Plechanovova et al.

NATURE (2012)

Article Biochemistry & Molecular Biology

BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer

Hao Dou et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)

Article Multidisciplinary Sciences

Parkin Promotes Degradation of the Mitochondrial Pro-Apoptotic ARTS Protein

Stav Kemeny et al.

PLOS ONE (2012)

Article Biochemistry & Molecular Biology

Solution structure of the E3 ligase HOIL-1 Ubl domain

Steven A. Beasley et al.

PROTEIN SCIENCE (2012)

Review Biochemistry & Molecular Biology

RINGs hold the key to ubiquitin transfer

Rhesa Budhidarmo et al.

TRENDS IN BIOCHEMICAL SCIENCES (2012)

Article Biochemistry & Molecular Biology

Mitochondrial dysfunction induced by knockdown of mortalin is rescued by Parkin

Hui Yang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Biochemistry & Molecular Biology

LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO

Jixiao Niu et al.

EMBO JOURNAL (2011)

Article Biochemistry & Molecular Biology

Autoregulation of Parkin activity through its ubiquitin-like domain

Viduth K. Chaugule et al.

EMBO JOURNAL (2011)

Article Biochemistry & Molecular Biology

Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation

Elena Maspero et al.

EMBO REPORTS (2011)

Article Biochemistry & Molecular Biology

Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant

Johanna M. Rose et al.

HUMAN MOLECULAR GENETICS (2011)

Article Biochemistry & Molecular Biology

The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability

Thomas M. Durcan et al.

HUMAN MOLECULAR GENETICS (2011)

Article Biochemistry & Molecular Biology

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy

Nickie C. Chan et al.

HUMAN MOLECULAR GENETICS (2011)

Article Biochemistry & Molecular Biology

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1

Liliane Glauser et al.

JOURNAL OF NEUROCHEMISTRY (2011)

Article Multidisciplinary Sciences

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

Fuminori Tokunaga et al.

NATURE (2011)

Article Multidisciplinary Sciences

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

Dawn M. Wenzel et al.

NATURE (2011)

Article Multidisciplinary Sciences

Linear ubiquitination prevents inflammation and regulates immune signalling

Bjoern Gerlach et al.

NATURE (2011)

Article Multidisciplinary Sciences

Mutations in PINK1 and Parkin Impair Ubiquitination of Mitofusins in Human Fibroblasts

Aleksandar Rakovic et al.

PLOS ONE (2011)

Article Multidisciplinary Sciences

HOIL-1L Interacting Protein (HOIP) Is Essential for CD40 Signaling

Bruce S. Hostager et al.

PLOS ONE (2011)

Article Multidisciplinary Sciences

Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex

Yusuke Sato et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Biochemistry & Molecular Biology

Naturally- and experimentally-designed restorations of the Parkin gene deficit in autosomal recessive juvenile parkinsonism

Hirohide Asai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

Article Biochemistry & Molecular Biology

IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation

Giovanni Benard et al.

EMBO JOURNAL (2010)

Article Biochemistry & Molecular Biology

Triad 1 induces apoptosis by p53 activation

Jin Hyuk Jung et al.

FEBS LETTERS (2010)

Article Biochemistry & Molecular Biology

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

Matthew E. Gegg et al.

HUMAN MOLECULAR GENETICS (2010)

Article Biochemistry & Molecular Biology

Differential Interaction of the E3 Ligase Parkin with the Proteasomal Subunit S5a and the Endocytic Protein Eps15

Susan S. Safadi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Cytoplasmic FANCA-FANCC Complex Interacts and Stabilizes the Cytoplasm-dislocalized Leukemic Nucleophosmin Protein (NPMc)

Wei Du et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy

Dong Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Cell Biology

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

Atsushi Tanaka et al.

JOURNAL OF CELL BIOLOGY (2010)

Article Cell Biology

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Sven Geisler et al.

NATURE CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

The structure of the catalytic subunit FANCL of the Fanconi anemia core complex

Ambrose R. Cole et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)

Article Multidisciplinary Sciences

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

Cristofol Vives-Bauza et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Differential control of TAp73 and ΔNp73 protein stability by the ring finger ubiquitin ligase PIR2

Berna S. Sayan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

Elena Ziviani et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation

David A. Boudreaux et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

Han Seok Ko et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Biochemistry & Molecular Biology

RING Domain E3 Ubiquitin Ligases

Raymond J. Deshaies et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Regulation of DNA repair by parkin

Shyan-Yuan Kao

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

Article Biochemistry & Molecular Biology

Parkin protects dopaminergic neurons from excessive Wnt/β-catenin signaling

Nina Rawal et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

Article Biochemistry & Molecular Biology

Parkin stabilizes PINK1 through direct interaction

Kahori Shiba et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

Article Biochemistry & Molecular Biology

Identification of a Novel Zn2+-binding Domain in the Autosomal Recessive Juvenile Parkinson-related E3 Ligase Parkin

Ventzislava A. Hristova et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Medicine, Research & Experimental

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

Hui Xiong et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

Article Neurosciences

Molecular interaction between parkin and PINK1 in mammalian neuronal cells

Ji Won Um et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2009)

Article Biochemistry & Molecular Biology

Insights into Ubiauitin Transfer Cascades from a Structure of a UbcH5B∼Ubiauitin-HECTNEDD4L Complex

Hari B. Kamadurai et al.

MOLECULAR CELL (2009)

Article Biochemistry & Molecular Biology

SH3 Domains from a Subset of BAR Proteins Define a Ubl-Binding Domain and Implicate Parkin in Synaptic Ubiquitination

Jean-Francois Trempe et al.

MOLECULAR CELL (2009)

Article Cell Biology

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

Fuminori Tokunaga et al.

NATURE CELL BIOLOGY (2009)

Article Biochemistry & Molecular Biology

E2 interaction and dimerization in the crystal structure of TRAF6

Qian Yin et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Article Cell Biology

DNA damage induces nuclear translocation of parkin

Shyan-Yuan Kao

JOURNAL OF BIOMEDICAL SCIENCE (2009)

Article Biochemistry & Molecular Biology

PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

Yongsung Kim et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

Article Biochemistry & Molecular Biology

Crystal structure and molecular dynamics simulation of ubiquitin-like domain of murine parkin

Koji Tomoo et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2008)

Article Biochemistry & Molecular Biology

α-Synuclein aggregates interfere with parkin solubility and distribution -: Role in the pathogenesis of Parkinson disease

Kohichi Kawahara et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Structural basis for ubiquitin recognition by the OTU1 ovarian tumor domain protein

Troy Eugene Messick et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment

Peter D. Mace et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Cell Biology

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Derek Narendra et al.

JOURNAL OF CELL BIOLOGY (2008)

Article Biochemical Research Methods

A targeted proteomic analysis of the ubiquitin-like modifier Nedd8 and associated proteins

Jeffrey Jones et al.

JOURNAL OF PROTEOME RESEARCH (2008)

Article Neurosciences

Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress

Furong Yu et al.

NEUROSCIENCE LETTERS (2008)

Article Biochemistry & Molecular Biology

Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD1

Jun-ichi Niwa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Multidisciplinary Sciences

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

Michaela U. Gack et al.

NATURE (2007)

Article Biochemistry & Molecular Biology

The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53

Lilia Kaustov et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Cell Biology

Compartmentalization of androgen receptor protein-protein interactions in living cells

Martin E. van Royen et al.

JOURNAL OF CELL BIOLOGY (2007)

Review Biochemistry & Molecular Biology

Regulation of catalytic activities of HECT ubiquitin ligases

Younghoon Kee et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Biochemistry & Molecular Biology

Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes

Christian Schlieker et al.

MOLECULAR CELL (2007)

Article Oncology

PARC and CUL7 form atypical cullin RING ligase complexes

Jeffrey R. Skaar et al.

CANCER RESEARCH (2007)

Article Multidisciplinary Sciences

Structure of the Parkin in-between-ring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson's disease

Steven A. Beasley et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Biochemistry & Molecular Biology

Parkin disrupts the alpha-synuclein/dopamine transporter interaction: Consequences toward dopamine-induced toxicity

Anna Moszczynska et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2007)

Article Biochemistry & Molecular Biology

Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex

Munehiro Nakamura et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Article Neurosciences

Functional modulation of parkin through physical interaction with SUMO-1

Ji Won Um et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2006)

Article Biochemistry & Molecular Biology

Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding

Colleen Fearns et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

A ubiquitin ligase complex assembles linear polyubiquitin chains

Takayoshi Kirisako et al.

EMBO JOURNAL (2006)

Article Biochemistry & Molecular Biology

Novel FXXFF and FXXMF motifs in androgen receptor cofactors mediate high affinity and specific interactions with the ligand-binding domain

Dennis J. van de Wijngaart et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin

Y Huang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Diverse effects of pathogenic mutations of parkin that catalyze multiple monoubiquitylation in vitro

N Matsuda et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Parkin ubiquitinates and promotes the degradation of RanBP2

JW Um et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis

J Huang et al.

FEBS LETTERS (2006)

Article Biochemistry & Molecular Biology

14-3-3η is a novel regulator of parkin ubiquitin ligase

S Sato et al.

EMBO JOURNAL (2006)

Article Biochemistry & Molecular Biology

The PUB domain functions as a p97 binding module in human peptide N-glycanase

Mark D. Allen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Multidisciplinary Sciences

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

WW Smith et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Parkin interacts with the proteasome subunit α4

JC Dächsel et al.

FEBS LETTERS (2005)

Article Biochemistry & Molecular Biology

Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development

JR Skaar et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

α-Synuclein and Parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains

EW Doss-Pepe et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Parkin stabilizes microtubules through strong binding mediated by three independent domains

F Yang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

RING finger ubiquitin-protein isopeptide ligase Nrdp1/FLRF regulates parkin stability and activity

L Zhong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity

A Yamamoto et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

DJ Moore et al.

HUMAN MOLECULAR GENETICS (2005)

Article Immunology

Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors

TH Chuang et al.

NATURE IMMUNOLOGY (2004)

Article Biochemistry & Molecular Biology

Ubiquitin interactions of NZF zinc fingers

SL Alam et al.

EMBO JOURNAL (2004)

Article Biochemistry & Molecular Biology

Recognition and accommodation at the androgen receptor coactivator binding interface

E Hur et al.

PLOS BIOLOGY (2004)

Article Multidisciplinary Sciences

Nitrosative stress linked to sporadic Parkinson's disease:: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity

DD Yao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Cell Biology

Parkin and relatives:: the RBR family of ubiquitin ligases

I Marín et al.

PHYSIOLOGICAL GENOMICS (2004)

Article Neurosciences

SEPT5_v2 is a parkin-binding protein

P Choi et al.

MOLECULAR BRAIN RESEARCH (2003)

Article Cell Biology

Parkin is recruited to the centrosome in response to inhibition of proteasomes

JH Zhao et al.

JOURNAL OF CELL SCIENCE (2003)

Article Biochemistry & Molecular Biology

Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1

T Ito et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1

CC Ng et al.

ONCOGENE (2003)

Article Biochemistry & Molecular Biology

Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function

YC Tsai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain

E Sakata et al.

EMBO REPORTS (2003)

Article Biochemistry & Molecular Biology

NMR structure of ubiquitin-like domain in PARKIN: Gene product of familial Parkinson's disease

M Tashiro et al.

JOURNAL OF BIOMOLECULAR NMR (2003)

Article Biochemistry & Molecular Biology

Parc: A cytoplasmic anchor for p53

AY Nikolaev et al.

Article Biochemistry & Molecular Biology

Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity

J Niwa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

The FXXLF motif mediates androgen receptor-specific interactions with coregulators

B He et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth

H Miyamoto et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Identification of molecular determinants required for interaction of ubiquitin-conjugating enzymes and RING finger proteins

G Martinez-Noel et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2001)

Article Biochemistry & Molecular Biology

A novel centrosomal RING-finger protein, Dorfin, mediates ubiquitin ligase activity

J Niwa et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)

Article Multidisciplinary Sciences

Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

Y Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

Article Biochemistry & Molecular Biology

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

Y Imai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Genetics & Heredity

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

H Shimura et al.

NATURE GENETICS (2000)