Journal
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
Volume 84, Issue 3, Pages F168-F171Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/fn.84.3.F168
Keywords
chronic lung disease; lungs; collagen; extracellular matrix; matrix metalloproteinase; preterm
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Objective-To assess whether increased collagenolysis precedes severe chronic lung disease (CLD). Methods-Matrix metalloproteinase-1 (MMP-1) and MMP-8 (enzymes that degrade type I collagen, the main structural protein of lung extracellular matrix) were measured by enzyme linked immunosorbent assay in 100 bronchoalveolar lavage samples taken during the first 6 postnatal days fi om 45 ventilated preterm babies <33 weeks gestation. The median value for each baby was calculated. CLD was defined as an oxygen requirement after the 36th week after conception. Results-MMP-8 levels in bronchoalveolar lavage fluid were higher (median 13 ng/ml) in 20 babies who developed CLD than in 25 without CLD (median 2 ng/ml). No MMP-1 was detected in any sample. Conclusions-MMP-8 can be detected in bronchoalveolar ravage fluid from preterm babies, and higher levels are found in those who later develop CLD. MMP-8 may contribute to lung injury that occurs as a prelude to CLD.
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