Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 75, Issue 2-3, Pages 273-277Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0378-8741(01)00176-3
Keywords
anti-inflammatory; Australian native plants; bioassay; Clerodendrum; Eremophila; Stemodia; xanthine oxidase
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Twenty-eight extracts from 17 species of Australian native plants traditionally used as general anti-inflammatory medicines by Australian Aboriginal people were examined for inhibition of the enzyme xanthine oxidase (XO). The extracts from nine species were found to have more than 25% inhibition at a concentration of 100 mug/ml in the assay mixture. Extracts from three species Clerodendrum floribundum showed the R. Br. (Verbenaceae), Eremophila maculata (Ker Gawler) (Myoporaceae) and Stemodia grossa Benth. (Scrophulariaceae) showed the greatest activity with inhibitions of 84, 61 and 57%, respectively, at 50 mug/ml, with four other species having more than 40% inhibitory activity at this concentration. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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