Journal
ARCHIVES OF ENVIRONMENTAL HEALTH
Volume 56, Issue 3, Pages 242-249Publisher
HELDREF PUBLICATIONS
DOI: 10.1080/00039890109604448
Keywords
antioxidants; asthma; bronchial hyperresponsiveness; diet; ozone
Funding
- NIDDK NIH HHS [DK35816] Funding Source: Medline
- NIEHS NIH HHS [P30 ES07033] Funding Source: Medline
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Ozone exposure aggravates asthma, as has been demonstrated in both controlled exposures and epidemiologic studies, In the current double-blind crossover study, the authors evaluated the effects of dietary antioxidants (i.e., 400 IU vitamin E/500 mg vitamin C) on ozone-induced bronchial hyperresponsiveness in adult subjects with asthma. Seventeen subjects were exposed to 0.12 ppm of ozone or to air for 45 min during intermittent moderate exercise. Bronchial hyperresponsiveness was assessed with 10-min sulfur dioxide (i.e., 0.10 ppm and 0.25 ppm) inhalation challenges. Subjects who were given dietary antioxidants responded less severely to su[fur dioxide challenge than subjects given a placebo (i.e., forced expiratory volume in the 1st sec: -1.2% vs. 4.4%, respectively; peak flow: +2.2% vs, -3.0%, respectively; and mid-forced expiratory flow: +2.0% vs. -4.3%, respectively). Effects were more pronounced when subjects were grouped by response to sulfur dioxide at the screening visit. The results suggest that dietary supplementation with vitamins E and C benefits asthmatic adults who are exposed to air pollutants.
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