Journal
BIOCHEMICAL JOURNAL
Volume 449, Issue -, Pages 11-23Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BJ20121323
Keywords
angiogenesis; genomic instability; inflammation; invasion/metastasis; metabolism; proliferation
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Funding
- Cancer Society of New Zealand [10/21, 11/07]
- Health Research Council of New Zealand [10/02]
- New Zealand Breast Cancer Research Trust [3621880]
- University of Otago Dean's Bequest (NZ)
- Canadian Institutes for Health Research
- Cancer Institute NSW [RLP 05/01]
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Hanahan and Weinberg have proposed the 'hallmarks of cancer' to cover the biological changes required for the development and persistence of tumours [Hanahan and Weinberg (201 1) Cell 144, 646-674]. We have noted that many of these cancer hallmarks are facilitated by the multifunctional protein YB-1 (Y-box-binding protein 1). In the present review we evaluate the literature and show how YB-1 modulates/regulates cellular signalling pathways within each of these hallmarks. For example, we describe how YB-1 regulates multiple proliferation pathways, overrides cell-cycle check points, promotes replicative immortality and genomic instability, may regulate angiogenesis, has a role in invasion and metastasis, and promotes inflammation. We also argue that there is strong and sufficient evidence to suggest that YB-1 is an excellent molecular marker of cancer progression that could be used in the clinic, and that YB-1 could be a useful target for cancer therapy.
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