Journal
ORAL DISEASES
Volume 7, Issue 3, Pages 192-195Publisher
MUNKSGAARD INT PUBL LTD
DOI: 10.1034/j.1601-0825.2001.70309.x
Keywords
hyperthermia; inductive heating; dextran magnetite complex
Categories
Ask authors/readers for more resources
The possibility of dextran magnetite complex (DM) as a new hyperthermic material was examined in this study. DM suspension of 56 mg ml(-1) iron concentration was locally injected into the normal tongue of golden hamster. DM injected tongues were heated by 500 kHz alternating current (AC) magnetic field and its serial changes in temperature were recorded at 30-s intervals, The temperature of DM injected tongue was maintained at about 43.0-45.0 degreesC for 30 min by changing the AC magnetic field intensity. While temperature elevations of the contralateral tongue and the rectum were only of minor degree, In experiment on the extent of heating area, there was correlation between volume of black stain area and amount of the injected DM suspension (Y = -18.1 + 1.94X, r = 0,931, P < 0.0001, n = 9), Histological examination after heating revealed brown uniform DM accumulation in the connective tissue between fibers of the tongue muscle. Except for vascular dilatations, no tissue damage was seen in the heated tongue. Thus, DM which has the possibility of selective and uniform heating in local hyperthermia might be useful for oral cancer therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available