Journal
BIOCHEMICAL JOURNAL
Volume 444, Issue -, Pages 357-373Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BJ20112208
Keywords
mitochondrion; ribosome biogenesis; RNA degradation; RNA polyadenylation; RNA turnover
Categories
Funding
- Medical Research Council
- Medical Research Council [MC_U105697135] Funding Source: researchfish
- MRC [MC_U105697135] Funding Source: UKRI
Ask authors/readers for more resources
Mammalian mitochondria contain their own genome that encodes mRNAs for thirteen essential subunits of the complexes performing oxidative phosporylation as well as the RNA components (two rRNAs and 22 tRNAs) needed for their translation in mitochondria. All RNA species are produced from single polycistronic precursor RNAs, yet the relative concentrations of various RNAs differ significantly. This underscores the essential role of post-transcriptional mechanisms that control the maturation, stability and translation of mitochondrial RNAs. The present review provides a detailed summary on the role of RNA maturation in the regulation of mitochondrial gene expression, focusing mainly on messenger RNA polyadenylation and stability control. Furthermore, the role of mitochondrial ribosomal RNA stability, processing and modifications in the biogenesis of the mitochondrial ribosome is discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available