Journal
MECHANISMS OF DEVELOPMENT
Volume 103, Issue 1-2, Pages 197-200Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(01)00357-4
Keywords
protein kinase C-theta; RNA in situ hybridization; hematopoiesis; lymphopoiesis; yolk sac; liver; thymus; spleen; afferent neuronal conduction; dorsal root ganglia; trigeminal and facial ganglia; alar plate; gracile and cuneate fasciculi; medial lemniscus; thalamus; olfactory system; mitral cell layer; of olfactory bulb; interneuron layer of praepiriform cortex amygdaloid area; medial habenulae; cerebellum; choroid plexus
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Protein kinase C (PKC)-theta, a serine/threonine protein kinase and novel PKC subfamily member, has been recently identified as an essential component of the T cell synapse which activates the NF-kB signaling cascade leading to expression of the IL-2 gene during T cell activation. By RNA in situ hybridization to whole-body embryo sections it is shown that the murine PKC theta is specifically expressed in tissues with hematopoietic and lymphopoietic activity. Expression is also evident in skeletal muscle. A further highly specific expression was observed in the peripheral and central nervous system which is described in detail. Expression in the brain persists up to adult stages. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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