Journal
BIOCHEMICAL JOURNAL
Volume 436, Issue -, Pages 409-414Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BJ20110084
Keywords
AAA plus ATPase; archaea; DNA replication; helicase; minichromosome maintenance (MCM); Sulfolobus
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Funding
- BBSRC (Biotechnology and Biological Sciences Research Council) [BB/G0006512/1]
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The MCM (minichromosome maintenance) proteins of archaea are widely believed to be the replicative DNA helicase of these organisms. Most archaea possess a single MCM orthologue that forms homo-multimeric assemblies with a single hexamer believed to be the active form. In the present study we characterize the roles of highly conserved residues in the ATPase domain of the MCM of the hyperthermophilic archaeon Sulfolobus solfataricus. Our results identify a potential conduit for communicating DNA-binding information to the ATPase active site.
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