Journal
BIOCHEMICAL JOURNAL
Volume 434, Issue -, Pages 189-199Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BJ20101974
Keywords
cancer; heterogeneity; quantitative analysis; kinase network; systems biology
Categories
Funding
- Bart's and the London Charity [297/997]
- Dancer Research UK [C27327/A9914]
- Biotechnological and Biological Sciences Research Council [BB/G015023/1]
- Institute of Cancer Research
- BBSRC [BB/G015023/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/G015023/1] Funding Source: researchfish
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MS (mass spectrometry) techniques are rapidly evolving to high levels of performance and robustness. This is allowing the application of these methods to the interrogation of signalling networks with unprecedented depth and accuracy. In the present review we discuss how MS-based multiplex quantification of kinase activities and phosphoproteomics provide complementary means to assess biological signalling activity. In addition, we discuss how a wider application of these analytical concepts to quantify kinase signalling will result in a more comprehensive understanding of normal and disease biology at the system level.
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