Journal
BIOCHEMICAL JOURNAL
Volume 434, Issue -, Pages 383-390Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BJ20110027
Keywords
Caenorhabditis elegans; dense core vesicle (DCV); Golgi; HID-1; membrane trafficking; RAB-2
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Funding
- National Science Foundation of China [30870564, 30900268]
- Beijing Natural Science Foundation [5092017]
- Major State Basic Research Program of the People's Republic of China [2010CB833701]
- CAS [KSCX2-SW-224]
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Peptide hormones and neuropeptides are packaged and stored in a specialized intracellular organelle called the dense core vesicle. It remains elusive how peptide cargoes are correctly sorted. In the present study, we show that a highly conserved Golgi-localized protein named HID-1 acts to prevent mis-sorting of peptide cargoes to lysosomes for degradation via a PtdIns3P-dependent trafficking pathway. Epistasis analysis suggests that rab-2 is epistatic to hid-1.
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