Journal
GENE
Volume 268, Issue 1-2, Pages 87-96Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-1119(01)00427-9
Keywords
dnmt1; DNA methylation; Rb; c-Jun; transactivation
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Rb, c-Jun and dnmt1 play critical roles in the process of cellular differentiation. We demonstrate that a regulatory region of murine dnmt1 contains an element which is responsible for transactivation by Rb and c-Jun in P19 embryocarcinoma cells which is not observed in Y1 adrenocarcinoma cells. During differentiation of P19 cells, the induction of Rb and c-Jun coincides with an increase of dnmt1 mRNA. Using linker scanning mutagenesis we identify the element that is responsible for this activation to be a non-canonical AP-1 site. Our data is an example of how a proto-oncogene activates its downstream effecters by recruiting a tumor suppressor. This interaction of Rb and a protooncogene might play an important role in differentiation. The responsiveness of dnmt1 to this type of signal is consistent with an important role for regulated expression of dnmt1 during cellular differentiation. (C) 2001 Published by Elsevier Science B.V. All rights reserved.
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