Journal
ORGANIC LETTERS
Volume 3, Issue 9, Pages 1331-1334Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol015712o
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Funding
- NCRR NIH HHS [RR 11966] Funding Source: Medline
- NIGMS NIH HHS [GM58822] Funding Source: Medline
- PHPPO CDC HHS [PHS 1 S10 RR10444] Funding Source: Medline
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[GRAPHICS] A new method for the synthesis of selenocysteine derivatives and selenocysteine-containing peptides is described. Fmoc-Sep methoxybenzylselenocysteine (1) was prepared and used for solid-phase synthesis of peptides with an N-terminal unprotected selenocysteine, Subsequent native chemical ligation with a peptide thioester provided a 17-mer that corresponds to the C-terminus of ribonucleotide reductase with selenocysteine in place of cysteine.
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