Journal
BIOCHEMICAL JOURNAL
Volume 430, Issue -, Pages 365-377Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BJ20100699
Keywords
disease therapy; nonsense-mediated mRNA decay (NMD); premature termination codon (PTC); PTC-related disease
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Funding
- EMBL
- Deutsche Forschungsgemeinschaft (DFG)
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NMD (nonsense-mediated mRNA decay) belongs to the best-studied mRNA surveillance systems of the cell, limiting the synthesis of truncated and potentially harmful proteins on the one hand and playing an initially unexpected role in the regulation of global gene expression on the other hand. In the present review, we briefly discuss the factors involved in NMD, the different models proposed for the recognition of PTCs (premature termination codons), the diverse physiological roles of NMD, the involvement of this surveillance pathway in disease and the current strategies for medical treatment of PTC-related diseases.
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