Journal
BIOCHEMICAL JOURNAL
Volume 427, Issue -, Pages 1-17Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BJ20091866
Keywords
diabetes; metabolic syndrome; metabolism; obesity; Wnt signalling
Categories
Funding
- Biotechnology and Biological Science Research Council [8/JF/16994, BB/E011950/1]
- Medical Research Council
- Diabetes UK [BDA:RD 06/0003237]
- European Union [LSHM-CT-2005-018734]
- Biotechnology and Biological Sciences Research Council [JF16994, BB/E011950/1] Funding Source: researchfish
- British Heart Foundation [PG/10/38/28359] Funding Source: researchfish
- Medical Research Council [G0600717B, G0802051] Funding Source: researchfish
- BBSRC [BB/E011950/1] Funding Source: UKRI
- MRC [G0802051] Funding Source: UKRI
Ask authors/readers for more resources
At the cellular level, the biological processes of cell proliferation, growth arrest, differentiation and apoptosis are all tightly coupled to appropriate alterations in metabolic status. In the case of cell proliferation, this requires redirecting metabolic pathways to provide the fuel and basic components for new cells. Ultimately, the successful co-ordination of cell-specific biology with cellular metabolism underscores multicellular processes as diverse as embryonic development, adult tissue remodelling and cancer cell biology. The Wnt signalling network has been implicated in all of these areas. While each of the Wnt-dependent signalling pathways are being individually delineated in a range of experimental systems, our understanding of how they integrate and regulate cellular metabolism is still in its infancy. In the present review we reassess the roles of Wnt signalling in functionally linking cellular metabolism to tissue development and function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available