4.4 Article

A practical chemoenzymatic synthesis of a key intermediate of antifungal agents

Journal

TETRAHEDRON LETTERS
Volume 42, Issue 19, Pages 3331-3333

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(01)00425-7

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A novel synthesis of an azole antifungal building block, the optically active diol, is described. The key step involves an enantioselective hydrolysis of a prochiral diester by a lipase. (C) 2001 Elsevier Science Ltd. All rights reserved.

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