Journal
BIOCHEMICAL JOURNAL
Volume 428, Issue -, Pages 11-23Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BJ20100102
Keywords
cell replacement therapy; human; regenerative medicine; stem cell
Categories
Funding
- AstarSTAR Graduate Academy of AstarSTAR (Agency for Science, Technology and Research), Singapore
- Medical Research Council (U.K.)
- MRC [G0701448] Funding Source: UKRI
- Medical Research Council [G0701448] Funding Source: researchfish
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Stem cells represent a unique opportunity for regenerative medicine to cure a broad number of diseases for which current treatment only alleviates symptoms or retards further disease progression. However, the number of stem cells available has speedily increased these past 10 years and their diversity presents new challenges to clinicians and basic scientists who intend to use them in clinics or to study their unique properties. In addition, the recent possibility to derive pluripotent stem cells from somatic cells using epigenetic reprogramming has further increased the clinical interest of stem cells since induced pluripotent stem cells could render personalized cell-based therapy possible. The present review will attempt to summarize the advantages and challenges of each type of stem cell for current and future clinical applications using specific examples.
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