Journal
CARBOHYDRATE RESEARCH
Volume 332, Issue 1, Pages 67-74Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0008-6215(01)00075-1
Keywords
fungus; Ganoderma lucidum; spores; conformational analysis; immunological activities
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A polysaccharide isolated from spores of the fungus, Ganoderma lucidum, was found to be a complex glucan. On the basis of compositional and methylation analyses, periodate oxidation, Smith degradation, 1D and 2D NMR, and ESIMS experiments of the native polysaccharide and its degraded products, the polysaccharide was shown to have a backbone of beta-(1 -->3)-linked D-glucopyranosyl residues, with branches of mono-, di- and oligosaccharide side chains substituting at the C-6 of the glucosyl residues in the main chain. Conformational analysis in aqueous solution and immunological activities of the native and degraded glucans were also investigated. The results suggested that the degree of substitution on the main chain and the length of side chains may be very important factors in determining the conformation and the biological activities of beta-(1 -->3)-linked glucans. (C) 2001 Elsevier Science Ltd. All rights reserved.
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