Journal
MUTATION RESEARCH-DNA REPAIR
Volume 485, Issue 4, Pages 283-307Publisher
ELSEVIER
DOI: 10.1016/S0921-8777(01)00063-5
Keywords
APE1; REF-1; abasic DNA; AP endonuclease; base excision repair; apurinic/apyrimidinic site
Funding
- NCI NIH HHS [CA79056] Funding Source: Medline
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DNA continuously suffers the loss of its constituent bases, and thereby, a loss of potentially vital genetic information. Sites of missing bases - termed abasic or apurinic/apyrimidinic (AP) sites - form spontaneously, through damage-induced hydrolytic base release, or by enzyme-catalyzed removal of modified or mismatched bases during base excision repair (BER). In this review, we discuss the structural and biological consequences of abasic lesions in DNA, as well as the multiple repair pathways for such damage, while emphasizing the mechanistic operation of the multi-functional human abasic endonuclease APE1 (or REF-1) and its potential relationship to disease. (C) 2001 Elsevier Science B.V. All rights reserved.
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