Journal
BIOCHEMICAL JOURNAL
Volume 422, Issue -, Pages 11-22Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BJ20090219
Keywords
cancer; diabetes; Keshan disease; multiminicore disease; neurodegeneration; selenium; selenocysteine; selenoprotein; thyroid hormone
Categories
Funding
- NCRR NIH HHS [G12 RR003061-245408, G12 RR003061] Funding Source: Medline
- NIMHD NIH HHS [G12 MD007601] Funding Source: Medline
- NINDS NIH HHS [R01 NS040302-05, R01 NS040302] Funding Source: Medline
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Selenoproteins are proteins containing selenium in the form of the 21st amino acid, selenocysteine. Members of this protein family have many diverse functions, but their synthesis is dependent on a common set of cofactors; and oil dietary selenium. Although the functions of many selenoproteins; are unknown, several disorders involving changes in selenoprotein structure, activity or expression have been reported. Selenium deficiency and mutations or polymorphisms in selenoprotein genes and synthesis cofactors are implicated in a variety of diseases, including muscle and cardiovascular disorders, immune dysfunction, cancer, neurological disorders and endocrine function. Members of this unusual family of proteins have roles in a variety of cell processes and diseases.
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