4.5 Review

Mechanisms of double-strand break repair in somatic mammalian cells

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair

Jennifer M. Svendsen et al.

Article Biochemistry & Molecular Biology

PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

Feng Zhang et al.

CURRENT BIOLOGY (2009)

Article Biochemistry & Molecular Biology

XRCC2 and XRCC3 Regulate the Balance between Short- and Long-Tract Gene Conversions between Sister Chromatids

Ganesh Nagaraju et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Roles for NBS1 in Alternative Nonhomologous End-Joining of V(D)J Recombination Intermediates

Ludovic Deriano et al.

MOLECULAR CELL (2009)

Article Biochemistry & Molecular Biology

Coordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair

Ivan M. Munoz et al.

MOLECULAR CELL (2009)

Article Biochemistry & Molecular Biology

Multiple functions of MRN in end-joining pathways during isotype class switching

Maria Dinkelmann et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Role of mammalian Mre11 in classical and alternative nonhomologous end joining

Anyong Xie et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

Emilie Rass et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Article Multidisciplinary Sciences

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

Shirley M. H. Sy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair

R. Scott Williams et al.

Article Cell Biology

Break-induced replication - What is it and what is it for?

Bertrand Llorente et al.

CELL CYCLE (2008)

Article Multidisciplinary Sciences

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

Eleni P. Mimitou et al.

NATURE (2008)

Article Multidisciplinary Sciences

53BP1 facilitates long-range DNA end-joining during V(D)J recombination

Simone Difilippantonio et al.

NATURE (2008)

Article Multidisciplinary Sciences

CDK targets Sae2 to control DNA-end resection and homologous recombination

Pablo Huertas et al.

NATURE (2008)

Article Multidisciplinary Sciences

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

Nadya Dimitrova et al.

NATURE (2008)

Article Multidisciplinary Sciences

Identification of Holliday junction resolvases from humans and yeast

Stephen C. Y. Ip et al.

NATURE (2008)

Article Multidisciplinary Sciences

Resistance to therapy caused by intragenic deletion in BRCA2

Stacey L. Edwards et al.

NATURE (2008)

Article Multidisciplinary Sciences

E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks

Latarsha J. Reid et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Biochemistry & Molecular Biology

Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance

Vilhelm A. Bohr

TRENDS IN BIOCHEMICAL SCIENCES (2008)

Article Biochemistry & Molecular Biology

Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair

Anyong Xie et al.

MOLECULAR CELL (2007)

Article Multidisciplinary Sciences

Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

Bin Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

Jose Guirouilh-Barbat et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

Nadine K. Kolas et al.

SCIENCE (2007)

Article Biochemistry & Molecular Biology

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

Michael S. Y. Huen et al.

Article Biochemistry & Molecular Biology

Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex

Bettina M. Lengsfeld et al.

MOLECULAR CELL (2007)

Article Multidisciplinary Sciences

Human CtIP promotes DNA end resection

Alessandro A. Sartori et al.

NATURE (2007)

Article Multidisciplinary Sciences

Rag mutations reveal robust alternative end joining

Barbara Corneo et al.

NATURE (2007)

Article Multidisciplinary Sciences

IgH class switching and translocations use a robust non-classical end-joining pathway

Catherine T. Yan et al.

NATURE (2007)

Article Multidisciplinary Sciences

Break-induced replication and telomerase-independent telomere maintenance require Pol32

John R. Lydeard et al.

NATURE (2007)

Article Immunology

Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination

Pauline Soulas-Sprauel et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2007)

Article Multidisciplinary Sciences

Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

Hongtae Kim et al.

SCIENCE (2007)

Article Multidisciplinary Sciences

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

Shuhei Matsuoka et al.

SCIENCE (2007)

Article Multidisciplinary Sciences

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

Bijan Sobhian et al.

SCIENCE (2007)

Article Multidisciplinary Sciences

Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends

Chun J. Tsai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

Patterns of somatic mutation in human cancer genomes

Christopher Greenman et al.

NATURE (2007)

Article Biochemistry & Molecular Biology

XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps

Jiafeng Gu et al.

EMBO JOURNAL (2007)

Article Biochemistry & Molecular Biology

Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C

Ganesh Nagaraju et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Review Cell Biology

Mechanism of homologous recombination: mediators and helicases take on regulatory functions

Patrick Sung et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Article Biochemistry & Molecular Biology

DNA-PK autophosphorylation facilitates Artemis endonuclease activity

Aaron A. Goodarzi et al.

EMBO JOURNAL (2006)

Article Multidisciplinary Sciences

Rad54 protein promotes branch migration of Holliday junctions

Dmitry V. Bugreev et al.

NATURE (2006)

Article Biochemistry & Molecular Biology

Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide

J San Filippo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

A role for Brca1 in chromosome end maintenance

JP McPherson et al.

HUMAN MOLECULAR GENETICS (2006)

Article Biochemistry & Molecular Biology

H2AX prevents DNA breaks from progressing to chromosome breaks and translocations

S Franco et al.

MOLECULAR CELL (2006)

Article Biochemistry & Molecular Biology

The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends

M Clerici et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human artemis

YM Ma et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA

F Moreno-Herrero et al.

NATURE (2005)

Article Genetics & Heredity

The Artemis: DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps

YM Ma et al.

DNA REPAIR (2005)

Review Cell Biology

Dynamic molecular linkers of the genome: the first decade of SMC proteins

A Losada et al.

GENES & DEVELOPMENT (2005)

Article Biochemistry & Molecular Biology

Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks

BPC Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Genetics & Heredity

Molecular analysis of sister chromatid recombination in mammalian cells

N Puget et al.

DNA REPAIR (2005)

Article Immunology

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells

Q Pan-Hammarström et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

Article Biochemistry & Molecular Biology

Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice

S Espejel et al.

EMBO REPORTS (2004)

Article Biochemistry & Molecular Biology

Telomere maintenance requires the RAD51D recombination/repair protein

M Tarsounas et al.

Article Multidisciplinary Sciences

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

JH Lee et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase

YG Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Control of sister chromatid recombination by histone H2AX

AY Xie et al.

MOLECULAR CELL (2004)

Article Biochemistry & Molecular Biology

A biochemically defined system for mammalian nonhomologous DNA end joining

YM Ma et al.

MOLECULAR CELL (2004)

Review Immunology

Class-switch recombination: Interplay of transcription, DNA deamination and DNA repair

J Chaudhuri et al.

NATURE REVIEWS IMMUNOLOGY (2004)

Article Biochemistry & Molecular Biology

Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells

J Guirouilh-Barbat et al.

MOLECULAR CELL (2004)

Review Cell Biology

Timeline - Happy Hollidays: 40th anniversary of the Holliday junction

YL Liu et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Regulation of telomere length and suppression of genomic instability in human somatic cells by Ku86

K Myung et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Review Biochemistry & Molecular Biology

Regulation of telomerase by telomeric proteins

A Smogorzewska et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break

R Shroff et al.

CURRENT BIOLOGY (2004)

Article Cell Biology

53BP1 is required for class switch recombination

IM Ward et al.

JOURNAL OF CELL BIOLOGY (2004)

Article Biochemistry & Molecular Biology

The role of DNA dependent protein kinase in synapsis of DNA ends

E Weterings et al.

NUCLEIC ACIDS RESEARCH (2003)

Article Biochemistry & Molecular Biology

Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast

G Ira et al.

Review Cell Biology

Mechanism and regulation of human non-homologous DNA end-joining

MR Lieber et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)

Article Biochemistry & Molecular Biology

Histone H2AX: A dosage-dependent suppressor of oncogenic translocations and tumors

CH Bassing et al.

Article Biochemistry & Molecular Biology

Pathways of DNA double-strand break repair during the mammalian cell cycle

K Rothkamm et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)

Article Biochemistry & Molecular Biology

Role of mammalian Rad54 in telomere length maintenance

I Jaco et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)

Article Biochemistry & Molecular Biology

Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability

JC Morales et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

p53 binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice

IM Ward et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)

Article Multidisciplinary Sciences

MDC1 is required for the intra-S-phase DNA damage checkpoint

M Goldberg et al.

NATURE (2003)

Article Multidisciplinary Sciences

MDC1 is a mediator of the mammalian DNA damage checkpoint

GS Stewart et al.

NATURE (2003)

Article Biochemistry & Molecular Biology

Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaks

JM Stark et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)

Article Biochemistry & Molecular Biology

Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice

S Rooney et al.

MOLECULAR CELL (2002)

Article Cell Biology

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

O Fernandez-Capetillo et al.

NATURE CELL BIOLOGY (2002)

Article Multidisciplinary Sciences

Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

L Pellegrini et al.

NATURE (2002)

Article Biochemistry & Molecular Biology

DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2

A Smogorzewska et al.

CURRENT BIOLOGY (2002)

Article Biochemistry & Molecular Biology

XRCC3 controls the fidelity of homologous recombination: Roles for XRCC3 in late stages of recombination

MA Brenneman et al.

MOLECULAR CELL (2002)

Article Biochemistry & Molecular Biology

Synapsis of DNA ends by DNA-dependent protein kinase

LG DeFazio et al.

EMBO JOURNAL (2002)

Article Cell Biology

Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III

T Caspari et al.

GENES & DEVELOPMENT (2002)

Article Multidisciplinary Sciences

Genomic instability in mice lacking histone H2AX

A Celeste et al.

SCIENCE (2002)

Review Biochemistry & Molecular Biology

Alternative lengthening of telomeres in mammalian cells

JD Henson et al.

ONCOGENE (2002)

Article Biochemistry & Molecular Biology

Human Mus81-associated endonuclease cleaves holliday junctions in vitro

XB Chen et al.

MOLECULAR CELL (2001)

Article Biochemistry & Molecular Biology

DNA polymerase stalling, sister chromatid recombination and the BRCA genes

R Scully et al.

ONCOGENE (2000)

Article Biochemistry & Molecular Biology

Coupled homologous and nonhomologous repair of a double-strand break preserves genomic integrity in mammalian cells

C Richardson et al.

MOLECULAR AND CELLULAR BIOLOGY (2000)

Article Genetics & Heredity

Telomere maintenance by recombination in human cells

MA Dunham et al.

NATURE GENETICS (2000)

Article Multidisciplinary Sciences

In search of the tumour-suppressor functions of BRCA1 and BRCA2

R Scully et al.

NATURE (2000)

Article Biochemistry & Molecular Biology

Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells

RD Johnson et al.

EMBO JOURNAL (2000)

Article Biochemistry & Molecular Biology

Ku recruits the XRCC4-ligase IV complex to DNA ends

SAN McElhinny et al.

MOLECULAR AND CELLULAR BIOLOGY (2000)